| Southampton Fixtures | Southampton Results | |||||||||||||||
| May 22 | 2022 | 16:00 | Leicester | 4 | 1 | Southampton | ||||||||||
| May 17 | 2022 | 19:45 | Southampton | 1 | 2 | Liverpool | ||||||||||
| May 7 | 2022 | 15:00 | Brentford | 3 | 0 | Southampton | ||||||||||
| April 30 | 2022 | 15:00 | Southampton | 1 | 2 | Crystal Palace | ||||||||||
| April 24 | 2022 | 14:00 | Brighton | 2 | 2 | Southampton | ||||||||||
| April 21 | 2022 | 19:45 | Burnley | 2 | 0 | Southampton | ||||||||||
| April 16 | 2022 | 15:00 | Southampton | 1 | 0 | Arsenal | ||||||||||
| April 9 | 2022 | 15:00 | Southampton | 0 | 6 | Chelsea | ||||||||||
| April 2 | 2022 | 15:00 | Leeds United | 1 | 1 | Southampton | ||||||||||
| March 13 | 2022 | 14:00 | Southampton | 1 | 2 | Watford | ||||||||||
| March 10 | 2022 | 19:30 | Southampton | 1 | 2 | Newcastle | ||||||||||
| March 5 | 2022 | 15:00 | Aston Villa | 4 | 0 | Southampton | ||||||||||
| February 25 | 2022 | 20:00 | Southampton | 2 | 0 | Norwich City | ||||||||||
| February 19 | 2022 | 15:00 | Southampton | 2 | 0 | Everton | ||||||||||
| February 12 | 2022 | 12:30 | Manchester U. | 1 | 1 | Southampton | ||||||||||
| February 9 | 2022 | 19:45 | Tottenham H. | 2 | 3 | Southampton | ||||||||||
| January 22 | 2022 | 17:30 | Southampton | 1 | 1 | Manchester C. | ||||||||||
| January 15 | 2022 | 15:00 | Wolves | 3 | 1 | Southampton | ||||||||||
| January 11 | 2022 | 19:45 | Southampton | 4 | 1 | Brentford | ||||||||||
| December 28 | 2021 | 15:00 | Southampton | 1 | 1 | Tottenham H. | ||||||||||
| December 26 | 2021 | 15:00 | West Ham U. | 2 | 3 | Southampton | ||||||||||
| December 15 | 2021 | 19:30 | Crystal Palace | 2 | 2 | Southampton | ||||||||||
| December 11 | 2021 | 15:00 | Arsenal | 3 | 0 | Southampton | ||||||||||
| December 4 | 2021 | 15:00 | Southampton | 1 | 1 | Brighton | ||||||||||
| December 1 | 2021 | 19:30 | Southampton | 2 | 2 | Leicester | ||||||||||
| November 27 | 2021 | 15:00 | Liverpool | 4 | 0 | Southampton | ||||||||||
| November 20 | 2021 | 15:00 | Norwich City | 2 | 1 | Southampton | ||||||||||
| November 5 | 2021 | 20:00 | Southampton | 1 | 0 | Aston Villa | ||||||||||
| October 30 | 2021 | 15:00 | Watford | 0 | 1 | Southampton | ||||||||||
| October 23 | 2021 | 15:00 | Southampton | 2 | 2 | Burnley | ||||||||||
| October 16 | 2021 | 15:00 | Southampton | 1 | 0 | Leeds United | ||||||||||
| October 2 | 2021 | 15:00 | Chelsea | 3 | 1 | Southampton | ||||||||||
| September 26 | 2021 | 14:00 | Southampton | 0 | 1 | Wolves | ||||||||||
| September 18 | 2021 | 15:00 | Manchester C. | 0 | 0 | Southampton | ||||||||||
| September 11 | 2021 | 15:00 | Southampton | 0 | 0 | West Ham U. | ||||||||||
| August 28 | 2021 | 15:00 | Newcastle | 2 | 2 | Southampton | ||||||||||
| August 22 | 2021 | 14:00 | Southampton | 1 | 1 | Manchester U. | ||||||||||
| August 14 | 2021 | 15:00 | Everton | 3 | 1 | Southampton | ||||||||||